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The only generics available Avalude this class of medication are Hyzaar and Cozaar. Higher doses of irbesartan ameliorated the hypokalemic response to hydrochlorothiazide. Potassium Supplements Advise patients not to use potassium supplements or salt substitutes containing potassium without consulting their healthcare provider [see Drug Interactions 7. Its empirical formula is C 25 H 28 N 6 O, and Afalide structural formula is: Irbesartan is a white to off-white crystalline powder with a molecular weight of Thiazides cross the placenta, and use of thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults. Stagger the dosage of hydrochlorothiazide and the resin such that AVALIDE is administered at least 4 hours before or 4 to 6 hours after the administration of the resin. Veterans Affairs Department. One tablet daily 2. ANDA applicants do not have to repeat the extensive clinical testing otherwise necessary to gain approval of a new drug application NDA. Avalide falls into category C during the first trimester. If the pharmacy doesn't regularly stock a certain medication from Teva, ask if it can be ordered for you at no additional cost. It is important to take this medication regularly and to follow your doctor's instructions regarding monitoring blood pressure to ensure that you receive the maximum benefit from the medication. Toenail Fungus: Treatment Options Table. Multum information has been Avalide for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of Avxlide United States are appropriate, unless specifically indicated otherwise. We have also independently evaluated relevant literature and data for possible postmarketing adverse events. The 7 studies of irbesartan monotherapy included a total of patients randomized to Avaliide 1 to mg and patients randomized to placebo. Black patients typically show an improved response with the addition of a low dose diuretic e. NDC 1 inactivated 2 inactivated 3 inactivated 4 inactivated 5 inactivated. Because of the potential for adverse effects on the nursing infant, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother. Administrative practice and procedure. Cholestyramine and Colestipol Resins: absorption of hydrochlorothiazide is impaired in the presence of anionic exchange resins. You should not use this medicine if you are unable to urinate, or if you are allergic to sulfa drugs. What is hydrochlorothiazide and irbesartan? Irbesartan is in a group of drugs called angiotensin II receptor antagonists. This medication is used to reduce high blood pressure. Hematologic: aplastic anemia, agranulocytosis, leukopenia, Avalide anemia, thrombocytopenia. In some cases, drinking too much Avapide can be as unsafe as not drinking enough. Irbesartan and its metabolites are excreted by both biliary and renal routes. Learn More. In most patients no benefit has been associated with using two Agalide inhibitors concomitantly. To find out if your medication is available as a Teva generic, contact your local pharmacy. Learn more here. Use effective birth control while taking hydrochlorothiazide and irbesartan. These medications have been moved to your Medicine Chest. This document has been published in the Federal Register. No carcinogenicity studies have been conducted with the irbesartan-hydrochlorothiazide combination. NDC 1 inactivated 2 inactivated 3 inactivated 4 inactivated 5 inactivated. Hydrochlorothiazide Hydrochlorothiazide is not metabolized but is eliminated rapidly by the kidney. Tell your doctor or prescriber about all prescription, over-the-counter non-prescriptionand herbal medications that you are taking. Gender No gender-related differences in pharmacokinetics were observed in healthy elderly age 65 to 80 years or in healthy young age 18 to 40 years subjects. Corticosteroids, ACTH —intensified electrolyte depletion, particularly hypokalemia. A transient hypotensive response is not a contraindication to further treatment, which usually can be continued without difficulty once the blood Avalice has Avalidd. Avalide dosage information in more detail. Avalide is a prescription medication used to treat high blood pressure. Cases of acute angle-closure glaucoma have been reported with hydrochlorothiazide. Enhanced Content - Document Tools. Irbesartan does not inhibit ACE or renin or affect other hormone receptors or ion channels known to be involved in the cardiovascular regulation of blood pressure and sodium homeostasis. Kimberly Hotz, PharmD. You may also be told to drink extra fluids. Hydrochlorothiazide can interfere with the results of a thyroid test. Irbesartan and its metabolites are excreted by both biliary and renal routes. You can easily become dehydrated while taking this medication, which can lead to severely low blood pressure or a serious electrolyte imbalance. Avalide Overdose Back to Top. Did you experience many side effects while taking this drug? The renin-aldosterone link is mediated by angiotensin II, so coadministration of an angiotensin II receptor antagonist tends to reverse the potassium loss Avalidde with these diuretics. Adverse events occurred at about the same rates in men and women, older and younger patients, and black and non-black patients. Dehydration may occur Agalide excessive sweating, diarrhea, or vomiting and Avallde not drinking enough liquids. I Accept. These factors may affect how you should use this medication. The dose-response relationships for effects on systolic and diastolic pressure are Avaalide in Figures Avalude and 4. The rates of Avalode due to adverse events were 2. There has been no known use of irbesartan in patients with unilateral or bilateral renal artery stenosis, but a similar effect should be anticipated. The renin-aldosterone link is mediated by angiotensin II, so coadministration of an angiotensin II receptor antagonist tends to reverse the potassium loss associated with these diuretics. Blood pressure should be monitored more often in these situations. An interaction between two medications does not always mean that you must stop taking one of them. Subcutaneous edema also occurred in fetuses at doses about 4 times the MRHD based on body surface area. Thiazides cross the placenta, and use of thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults. Avalide reviews. No data are available in regard to overdosage in humans. Daily news summary. All patients receiving thiazide therapy should be observed for clinical signs of fluid or electrolyte imbalance: hyponatremia, hypochloremic alkalosis, and hypokalemia. Thiazides have been shown to increase the urinary excretion of magnesium; this may result in hypomagnesemia. Trade Adjustment Assistance 77 documents in the last year. International Trade Anti-Dumping documents in Avalive last year. Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. What is the most important information I should know about hydrochlorothiazide and irbesartan? Increases in serum lithium concentrations and lithium toxicity have been reported with concomitant use of irbesartan or thiazide diuretics. Other adverse events that have been reported with irbesartan, without regard to causality, are listed below:. Avoid exposure to the sun and sunlamps until you know how Avalide affects you. Talk to your pharmacist about the potential option s noted below. It is not known whether hydrochlorothiazide and irbesartan passes into breast milk or if it could harm a nursing baby. This document has been published in the Federal Register. Thiazides may decrease urinary calcium excretion. Print this document. No dosage adjustment is necessary in the elderly. Patients with stage 2 moderate or severe hypertension are at relatively high risk for cardiovascular events such as strokes, heart attacks, and heart failurekidney failure, and vision problems, so prompt treatment is clinically relevant. Maximum effects were seen at Week 7. Please re-enter and try again. Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. Initial therapy: Hydrochlorothiazide Modify Search. Contraindications: Anuria.
Active Ingredient: Irbesartan
Avalide is used for treating high blood pressure.
Analogs of Avalide:

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    Avalide is used for treating high blood pressure. Avalide is a combination angiotensin II receptor blocker and diuretic. The angiotensin II receptor blocker works by relaxing the blood vessels.


    Use Avalide as directed by your doctor.

    • Avalide may be taken with or without food.
    • Drinking extra fluids while you are taking Avalide is recommended. Check with your doctor for instructions.
    • Avalide may increase the amount of urine or cause you to urinate more often when you first start taking it. To keep this from disturbing your sleep, try to take your dose before 6 pm.
    • If you take cholestyramine or colestipol, ask your doctor or pharmacist how to take it with Avalide.
    • Continue to take Avalide even if you feel well. Do not miss any doses.
    • If you miss a dose of Avalide, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

    Ask your health care provider any questions you may have about how to use Avalide.


    Store Avalide at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Avalide out of the reach of children and away from pets.


    Active Ingredients: Irbesartan hydrochlorothiazide.

  • Do NOT use Avalide if:

    • you are allergic to any ingredient in Avalide or to any other sulfonamide medicine (eg, sulfamethoxazole)
    • you are pregnant
    • you have severe kidney problems or are unable to urinate
    • you are taking dofetilide or ketanserin.

    Contact your doctor or health care provider right away if any of these apply to you.

    Some medical conditions may interact with Avalide. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

    • if you are planning to become pregnant or are breast-feeding
    • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
    • if you have allergies to medicines, foods, or other substances
    • if you have ever had a severe reaction (eg, swelling of the hands, face, lips, eyes, throat, or tongue; trouble swallowing or breathing; hoarseness) after taking any other angiotensin II receptor blocker or an angiotensin converting enzyme (ACE) inhibitor (eg, captopril)
    • if you are dehydrated; have low blood volume; have low blood sodium, chloride, potassium, or magnesium levels; or have high blood calcium levels
    • if you have asthma; diabetes; gout; heart problems (eg, congestive heart failure); liver, gall bladder, or kidney problems; high blood cholesterol or lipid levels; or systemic lupus erythematosus
    • if you have recently had nerve surgery.

    Some medicines may interact with Avalide. Tell your health care provider if you are taking any other medicines, especially any of the following:

    • Dofetilide or ketanserin because the risk of irregular heartbeat may be increased
    • Adrenocorticotropic hormone (ACTH), barbiturates (eg, phenobarbital), corticosteroids (eg, prednisone), diuretics (eg, furosemide), narcotic pain medicines (eg, morphine), or other medicines for high blood pressure because they may increase the risk of Avalide's side effects
    • Cholestyramine, colestipol, or nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen) because they may decrease Avalide's effectiveness
    • Diazoxide, digoxin, lithium, nondepolarizing muscle relaxants (eg, tubocurarine), potassium, or potassium-sparing diuretics (eg, spironolactone) because risk of their side effects and toxic effects may be increased by Avalide
    • Diabetes medicine (eg, glipizide, metformin), insulin, or pressor amines (eg, norepinephrine) because their effectiveness may be decreased by Avalide.

    This may not be a complete list of all interactions that may occur. Ask your health care provider if Avalide may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

    Important safety information:

    • Avalide may cause drowsiness, dizziness, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Avalide with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.
    • Avalide may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
    • Report any lightheadedness or fainting to your doctor immediately. Your risk of lightheadedness or fainting may be increased if you experience diarrhea, vomiting, excessive sweating, if you do not drink enough fluids, or if you are on a low-salt diet.
    • Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel normal. Tell your doctor if you develop any new symptoms.
    • Avalide may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Avalide. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
    • Tell your doctor or dentist that you take Avalide before you receive any medical or dental care, emergency care, or surgery.
    • If you have high blood pressure, do not use nonprescription products that contain stimulants. These products may include diet pills or cold medicines. Contact your doctor if you have any questions or concerns.
    • Your doctor may have also prescribed a potassium supplement for you. If so, follow the dosing carefully. Do not start taking additional potassium on your own or change your diet to include more potassium without first checking with your doctor.
    • Check with your doctor before you use a salt substitute or a product that has potassium in it.
    • Diabetes patients - Avalide may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
    • Avalide may raise your blood sugar. High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these symptoms occur, tell your doctor right away.
    • Avalide may interfere with certain lab tests, including parathyroid function tests. Be sure your doctor and lab personnel know you are taking Avalide.
    • Lab tests, including kidney function, blood pressure, and blood electrolytes, may be performed while you use Avalide. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
    • Use Avalide with caution in the elderly; they may be more sensitive to its effects.
    • Avalide should be used with extreme caution in children; safety and effectiveness in children have not been confirmed.
    • Pregnancy and breast-feeding: Avalide may cause birth defects or fetal death if you take it while you are pregnant. If you think you may be pregnant, contact your doctor right away. Avalide is found in breast milk. Do not breastfeed while taking Avalide.
  • All medicines may cause side effects, but many people have no, or minor, side effects.

    Check with your doctor if any of these most common side effects persist or become bothersome:

    Dizziness; nausea; tiredness; vomiting.

    Seek medical attention right away if any of these severe side effects occur:

    Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; confusion; decrease in sexual ability; depression; drowsiness; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; decreased urination; hoarseness; muscle pain, tenderness, or cramps; red, swollen, blistered, or peeling skin; restlessness; seizures; severe or persistent dry mouth; severe or persistent vomiting; shortness of breath; swelling of the arms or legs; unusual bruising or bleeding; unusual thirst; unusual tiredness or weakness; yellowing of the skin or eyes.

    This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.