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These lists contain examples of serious Jaunvia effects that can occur with Januvia, with metformin, or with both drugs when taken individually. Januviw stops the activity of a protein called dipeptidyl peptidase 4 DPP Some may be better suited for you than others. This section contains information intended for health care professionals in the United States only and is not intended for the general public. What is the truth about type 2 diabetes? Common questions about Januvia. Your doctor shall determine which dose of Januvia you will be taking. Also, GLP-1 acts on pancreatic alpha cells and reduces the levels of glucagon. We are not responsible for the content or availability of linked sites. Visit www. The Food and Drug Administration FDA has approved both Januvia and metformin to treat type 2 diabetes in adults, along with diet and exercise. Incretin mimetics or GLP-1 analogs boost GLP-1 levels artificially to supra-physiological levels while incretin-enhancers inhibit the dipeptidyl peptidase-4 DPP-4 enzyme - which normally degrades endogenously-produced GLP-1 within a few minutes - so as to prolong its activity. Incretin, a hormone, raises insulin levels when your levels of blood sugar go up and decreases the amount of sugar made by the body. Your blood sugar may need to be checked often, and you may need other blood tests at your doctor's office. There has never been a better time to introduce new medicines that can improve on the current range of anti-diabetic drugs, which includes biguanides metforminalpha glucosidase inhibitors, sulphonylureas, thiazolidinediones, meglitinides, and insulin. Insulin or drugs that help your body make insulin can interact with Januvia. Author disclosure: Nothing to disclose. When JANUVIA was used in combination with a sulfonylurea or insulin, medications known to cause hypoglycemia, the incidence of hypoglycemia was increased over that of placebo. You can also ask your pharmacist for information on how to dispose of your medication. The healthy glucagon-insulin balance is lost resulting in both fasting and postprandial hyperglycaemia. Subscribe to Drugs. Many people have misconceptions about type 2 diabetes. Letter from the Editor: The importance of accurate reporting. Consider the risks and benefits of JANUVIA prior to initiating treatment in patients at risk for heart failure, such as those with a prior history of heart failure and a history of renal impairment, and observe these patients for signs and symptoms of heart failure during therapy. However, other studies have looked at whether Januvia may help people lose weight. Incretin hormones are released from intestinal cells in response to carbohydrate- or fat-rich meals and stimulate pancreatic beta cells to release insulin, which stops hepatic glucose production. Januvia is meant to be used as an ongoing treatment. You may need to take medication to get your blood sugar to a safe level. Purchase Access: See My Options close. After taking Januvia, it may be about a week until your blood sugar level starts to decrease. So your pancreas tries to make more insulin to help control your blood sugar. Also tell them about any vitamins, herbs, and supplements you use. Sitagliptin is available in mg, mg, and mg tablets taken once daily, regardless of meals or time of day. Januvia and breastfeeding. In addition, higher levels of GLP-1 cause your body to release less of a hormone called glucagon. Inactivation of these hormones by DPP-4 prevents them from functioning and promotes hyperglycemia. A very serious allergic reaction to Januvia is rare. Low blood sugar is likely to occur after drinking large amounts of beverages containing alcohol, do not eat enough food, or if you perform unusually heavy exercise. These may Januvia symptoms of heart failure. But drinking too much alcohol can decrease the level of Januvvia sugar in your blood. Your doctor may Jannuvia to adjust your diabetes medications. Other incretin-mimetics are in development, including a long-acting once-weekly injection of exenatide, using slow-release polymeric microspheres being developed by Lilly in collaboration with Alkermes. Inform your doctor of any serious side effects, including signs of kidney problems, unusual skin blisters, joint pain, and signs of heart failure. Merck notes:. FDA alerts for all medications. They may also adjust the dosage of your diabetes medications. Follow all directions on your prescription label and read all medication guides or instruction sheets. The incretin mimetic Byetta Exenatide, Lillyadministered by injection, delays gastric emptying and increases satiety leading to weight loss of around 4 to 5 kgs over two years. This is a swelling of the pancreas, the organ that creates the hormone insulin. Consult your doctor to find out your best course of action when you skip a meal. More studies are needed to know the specific risk of having joint pain while taking Januvia. More studies are needed to know the specific risk of Janvia joint pain while taking Januvia. Allergic reactions to Januvia occur within three months Januvia starting the medication. Be sure your family Jnauvia close friends know how to give you this Januvka in an emergency. Interactive image. The pain may be felt going from your abdomen through to your back. Jauvia, tell your doctor if you have symptoms of kidney failure. Weekly news roundup. Incretin hormones are released by the intestine. In one clinical study that lasted 18 weeks, Januvia was tested in people with type 2 diabetes. Patients experienced relief of symptoms upon discontinuation of the medication. The following information describes dosages that are commonly used or recommended. Here we look at how Januvia and Tradjenta are alike and different. How Januvia works. It helps reduce the amount of sugar in your blood. Disclaimer : Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. Symptoms of edema can include swelling in some parts of your body, such as your hands and legs. Your immune system is what protects your Januviia from infections. A more severe allergic reaction is rare but possible. Whether or aJnuvia you need to take insulin depends on Januviq amount of sugar in your blood. Incretin, a Jnuvia, raises Januvia levels when your levels of blood sugar go up and decreases the amount of sugar made by the body. This is a swelling of the pancreas, the organ that creates Janubia hormone insulin. If you need financial support to pay for Januvia, or if you need help understanding your insurance coverage, help is available. Both have similar good tolerability profiles with regard to weight-neutrality and freedom from hypoglycaemic episodes and other side effects. The incretin mimetic Byetta Exenatide, Lillyadministered by injection, delays gastric emptying and increases satiety leading to weight loss of around 4 to 5 kgs over two years. One study presented at EASD showed when Galvus was added to insulin in people with poor diabetes control, patients, especially overs, experienced fewer hypoglycaemic episodes than with insulin plus placebo. Tell your doctor if you have a history of heart failure. So any company that sees the slightest side effect with their DPP-4 inhibitor should give it up right away. Talk to your doctor if there is a need to lower the dose of Januvia that you are taking. Angioedema has also been observed in people taking other DPP-4 inhibitors. Monthly newsletter. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing Jamuvia therapy in patients with type 2 diabetes inadequately controlled with metformin alone. This is not a complete list of side effects and others may occur. Januvia is a brand-name prescription medication. Email Alerts Don't miss a single issue. In diabetes, however, the normal incretin response Januiva lost, GLP-1 secretion is reduced by around 25 per cent, beta cells are reduced in number and are under-active; insulin feedback to alpha cells is diminished so these are persistently overactive. But researchers are studying how certain foods and supplements can increase or decrease the amount of sugar in your body. DPP-4 inhibitors Galvus and Januvia will be the first oral drugs tackling Type 2 diabetes via the incretin response: how do they compare? They can discuss the pros and cons with you. Diabetes Care. There have been postmarketing reports of serious hypersensitivity reactions in patients treated with JANUVIA, such as anaphylaxis, angioedema, and exfoliative skin conditions including Stevens-Johnson syndrome. Common side effects include headaches, swelling of the legs, and upper respiratory tract infections. Of the two products, Galvus has been more extensively studied. The pain may happen with or without vomiting. All of these have tolerability problems of one type or another such as gastro-intestinal disturbance, weight-gain, fluid-retention and hypoglycaemic episodes. Januvia dosage The usual recommended dose of Januvia is one tablet taken once daily. Visit www. JANUVIA should not be used in patients with Janufia 1 diabetes or with diabetic ketoacidosis increased ketones in the blood or urine. Call your doctor if you have severe joint pain. Januvia acts by inhibiting an enzyme known as dipeptidyl peptidase 4 DPP Merck may be able to help. Use: As an adjunct to diet and exercise to improve glycemic control in patients Janhvia type 2 diabetes mellitus. More studies are needed. It is slightly less effective than metformin when used as a monotherapy. Sitagliptin Januvia is an incretin enhancer and the first medication from the gliptin class to be marketed. Hypersensitivity reactions including anaphylaxis, angioedema, rash, urticaria, cutaneous vasculitis, and exfoliative skin conditions including Stevens-Johnson syndrome; hepatic enzyme elevations; acute pancreatitis, including fatal and nonfatal hemorrhagic and necrotizing pancreatitis; worsening renal function, including acute kidney injury sometimes requiring dialysis ; severe and disabling arthralgia; constipation; vomiting; headache; myalgia; pain in extremity; back pain; pruritus; pemphigoid. They may also adjust the dosage of your diabetes medications. Below is a list of medications that can interact with Januvia. Diabetes Care. J Clin Pharmacol. Stop taking Januvia and call your doctor if you have symptoms of pancreatitis : severe pain in your upper stomach spreading to your back, with or without vomiting. Januvia is not for treating type 1 diabetes. Related: Diabetes. Although Januvia by itself will not cause low blood sugar or hypoglycemia, low Janvia may occur when Januvia is prescribed along with Jankvia diabetes medications. Your body helps control the amount of sugar in your blood with a type of hormone called insulin. Januvia expiration, storage, and disposal. If you have had pancreatitis inflammation of the pancreasit is not known if you have a higher chance of getting it while taking JANUVIA. Callor in an emergency call Merck does not endorse and is not responsible for the accuracy, content, practices, or standards of any non-Merck site. Subscribe to Drugs. More studies are needed. Pay special attention in people with a history of angioedema with another DPP Retrieved 1 September
Januvia
Januvia
Active Ingredient: Sitagliptin
Januvia is used for treating type 2 diabetes in patients who cannot control blood sugar levels by diet and exercise alone.
Other names for this medication:
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  • INDICATIONS

    Januvia is used for treating type 2 diabetes in patients who cannot control blood sugar levels by diet and exercise alone. It is used along with diet and exercise. It may be used alone or with other antidiabetic medicines. Januvia is a dipeptidyl peptidase-4 (DPP-4) inhibitor. It works by increasing the amount of insulin released by your body, and decreasing the amount of sugar made by your body.

    INSTRUCTIONS 

    INDICATIONS

    Januvia is used for treating type 2 diabetes in patients who cannot control blood sugar levels by diet and exercise alone. It is used along with diet and exercise. It may be used alone or with other antidiabetic medicines. Januvia is a dipeptidyl peptidase-4 (DPP-4) inhibitor. It works by increasing the amount of insulin released by your body, and decreasing the amount of sugar made by your body.

    INSTRUCTIONS

    Use Januvia as directed by your doctor.

    • Take Januvia by mouth with or without food.
    • Take Januvia on a regular schedule to get the most benefit from it.
    • Continue to take Januvia even if you feel well. Do not miss any doses.
    • If you miss a dose of Januvia, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

    Ask your health care provider any questions you may have about how to use Januvia.

    STORAGE

    Store Januvia at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Januvia out of the reach of children and away from pets.

    MORE INFO:

    Active Ingredient: Sitagliptin.

  • Do NOT use Januvia if:

    • you are allergic to any ingredient in Januvia
    • you have type 1 diabetes
    • you have high blood ketone levels (diabetic ketoacidosis).

    Contact your doctor or health care provider right away if any of these apply to you.

    Some medical conditions may interact with Januvia. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

    • if you are pregnant, planning to become pregnant, or are breast-feeding
    • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
    • if you have allergies to medicines, foods, or other substances
    • if you have kidney problems
    • if you have a history of inflammation of the pancreas (pancreatitis).

    Some medicines may interact with Januvia. Tell your health care provider if you are taking any other medicines, especially any of the following:

    • Digoxin or sulfonylureas (eg, glipizide) because the risk of their side effects may be increased by Januvia.

    This may not be a complete list of all interactions that may occur. Ask your health care provider if Januvia may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

    Important safety information:

    • Follow the diet and exercise program given to you by your health care provider. Proper diet, regular exercise, and regular blood sugar testing are important for best results with Januvia.
    • Check your blood sugar levels as directed by your doctor. If they are often higher or lower than they should be and you take Januvia exactly as prescribed, tell your doctor.
    • It may be harder to control your blood sugar during times of stress such as fever, infection, injury, or surgery. Talk with your doctor about how to control your blood sugar if any of these occur. Do not change the dose of your medicine without checking with your doctor.
    • Januvia usually does not cause low blood sugar. However, low blood sugar may occur when it is used along with certain other medicines for diabetes (eg, sulfonylureas). Low blood sugar may make you anxious, sweaty, weak, dizzy, drowsy, or faint. It may also make your heart beat faster; make your vision change; give you a headache, chills, or tremors; or make you hungrier. It is a good idea to carry a reliable source of glucose (eg, tablets, gel) to treat low blood sugar. If this is not available, you should eat or drink a quick source of sugar like table sugar, honey, candy, orange juice, or non-diet soda. This will raise your blood sugar level quickly. Tell your doctor right away if this happens. To prevent low blood sugar, eat meals at the same time each day and do not skip meals.
    • Lab tests, including fasting blood glucose, glycosylated hemoglobin, and kidney function, may be performed while you use Januvia. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
    • Use Januvia with caution in the elderly; they may be more sensitive to its effects.
    • Januvia should be used with extreme caution in children younger 18 years; safety and effectiveness in these children have not been confirmed.
    • Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Januvia while you are pregnant. It is not known if Januvia is found in breast milk. If you are or will be breast-feeding while you use Januvia, check with your doctor. Discuss any possible risks to your baby.
  • All medicines may cause side effects, but many people have no, or minor, side effects.

    Check with your doctor if any of these most common side effects persist or become bothersome:

    Diarrhea; headache; nausea; runny or stuffy nose; sore throat; upper respiratory infection; upset stomach.

    Seek medical attention right away if any of these severe side effects occur:

    Severe allergic reactions (rash; hives; itching; difficulty breathing or swallowing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); fever, chills, or persistent sore throat; red, blistered, swollen, or peeling skin; symptoms of pancreas inflammation (eg, severe stomach or back pain with nausea or vomiting, stomach tenderness or swelling, fast heartbeat, dizziness).

    This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.